2024
Foster, D.; Williams, L.; Arnold, N.; Larsen, J. Therapeutic developments for neurodegenerative GM1 gangliosidosis. Frontiers in Neuroscience. 18:1392683 (2024). https://doi.org/10.3389/fnins.2024.1392683
Forenzo, C.; Larsen, J. Bridging Clinical Radiotherapy and Space Radiation Therapeutics through Reactive Oxygen Species (ROS)-Triggered Delivery. (2024). https://doi.org/10.1016/j.freeradbiomed.2024.04.219
Foster, D.; Cakley, A.; Larsen, J. Optimizing enzyme-responsive polymersomes for protein-based therapies. Nanomedicine, 19, 3 (2024). https://doi.org/10.2217/nnm-2023-0300
Williams, L., Larsen, J. Nanoparticle-Mediated Delivery of Non-viral Gene Editing Technology to the Brain. Progress in Neurobiology, 232, 102547 (2024). https://doi.org/10.1016/j.pneurobio.2023.102547
2023
Forenzo, C.; Larsen, J. Complex Coacervates as a Promising Vehicle for mRNA Delivery: A Comprehensive Review of Recent Advances and Challenges. Molecular Pharmaceutics 2023, 20, 9, 4387-4403. https://doi.org/10.1021/acs.molpharmaceut.3c00439
Huang, K.; Pitman, M.; Oladosu, O.; Echesabal-Chen, J.; Vojtech, L.; Esobi, I.; Larsen, J.; Jo, H.; Stamatikos, A. The Impact of MiR-33a-5p Inhibition in Pro-Inflammatory Endothelial Cells. Diseases 2023, 11, 88. https://doi.org/10.3390/diseases11030088
Larsen, J. Embrace Compassion. Science. Vol. 379. Issue 6638. 1266, (2023). https://doi.org/10.1126/science.adh8519
Foster, D., Larsen, J. Polymeric Metal Contrast Agents for T1-weighted Magnetic Resonance Imaging of the Brain. ACS Biomaterials Science and Engineering. 2023. https://doi.org/10.1021/acsbiomaterials.2c01386
Larsen, J. The Larsen Lab: A Center for Nanotherapeutic Strategies in the Central Nervous System (CNS2). Journal of the South Carolina Academy of Science, Vol. 21: Iss. 1, Article 3. January 2023. https://scholarcommons.sc.edu/jscas/vol21/iss1/3
2022
Iqbal, S., Alexander-Bryant, A., Larsen, J. (2022). Polymer-Mediated Delivery of CRISPR-Cas9 Genome-Editing Therapeutics for CNS Disease. In: Nance, E. (eds) Engineering Biomaterials for Neural Applications. Springer, Cham. https://doi.org/10.1007/978-3-031-11409-0_6
Tabah, O., Pierce, C., Larsen, J. Polyethylene Glycol-b-polylactic Acid Polymersome Elongation Through Osmotic Pressure Mediated Membrane Tension and Fusion. ChemRxiv. Cambridge: Cambridge Open Engage; 2022.
Paruchuri, B.; Smith, S.; Larsen, J. Enzyme-responsive polymersomes ameliorate autophagic failure in a cellular model of GM1 Gangliosidosis. Bioengineering and Translational Medicine. Frontiers in Chemical Engineering. Oct 2022. DOI: https://doi.org/10.3389/fceng.2022.997607
2021
Kanduri, V.; LaVigne, D.; Larsen, J. Current Advances Towards the Encapsulation of Cas9. ACS Macro Letters. 2021, 10, 12, 1576-1589 DOI: https://doi.org/10.1021/acsmacrolett.1c00538
Paruchuri, B.; Gopal, V.; Sarupria, S.; Larsen, J. Towards enzyme-responsive polymersome drug delivery. Nanomedicine. 16:30, 2679-2693. 6 Dec 2021. DOI: https://doi.org/10.2217/nnm-2021-0194
Pierce, C.; Katterman, C.; Larsen, J.; Modulating Shape of Polyester Based Polymersomes using Osmotic Pressure. Journal of Visual Experiments (170), e62548, 2021 DOI: https://doi.org/10.3791/62548
Katterman, C.; Pierce, C.; Larsen, J.; Combining Nanoparticle Shape Modulation and Polymersome Technology in Drug Delivery. ACS Applied Bio Materials 2021. 8 Mar 2021. DOI: https://doi.org/10.1021/acsabm.1c00203
2020
Maghak, L.; Larsen, J. Intact or In Pieces? A Look at How Clinically-Approved, Biodegradable Block Co-Polymers Affect Blood Components. ACS Biomaterials Science & Engineering 2020 6 (9), 4846-4850; DOI: https://doi.org/10.1021/acsbiomaterials.0c00680
Pitman, M. A.; Larsen, J. Characterization of Self-Assembling Nanostructures in Whole Blood. Analytical Methods. 3 Apr 2020. doi: https://doi.org/10.1039/D0AY00170H
Iqbal, S., Blenner, M., Alexander-Bryant, A., Larsen, J. Polymersomes for Therapeutic Delivery of Protein and Nucleic Acid Macromolecules: From Design to Therapeutic Applications. Biomacromolecules. 2020. DOI: https://doi.org/10.1021/acs.biomac.9b01754
Smith, S.; Larsen, J. Linking Enzyme Upregulation to Autophagic Failure: A Potential Biomarker for GM1 Gangliosidosis. bioRxiv 2020.10.28.359083; DOI: https://doi.org/10.1101/2020.10.28.359083
L'Amoreaux, N., Ali, A., Iqbal, S., Larsen, J. Persistent Prolate Polymersomes for Enhanced Co-Delivery of Hydrophilic and Hydrophobic Drugs. Nanotechnology. Accepted Manuscript online 15 January 2020. PMCID: 31940601 DOI: https://doi.org/10.1088/1361-6528/ab6bf1
pre-
2020
L'Amoreaux, N.; Ali, A.; Iqbal, S.; Larsen, J. Persistent Prolate Polymersomes for Enhanced Co-Delivery of Hydrophilic and Hydrophobic Drugs. bioRxiv 796201; (2019) doi: https://doi.org/10.1101/796201
Kelly, J.M.; Gross, A.; Martin, D.R.; Byrne, M.E. “Polyethylene glycol-b-Poly(lactic acid) Polymersomes as Vehicles for Enzyme Replacement Therapy”, Nanomedicine, 2591-2606, (2017). PMCID: 29111890
Kelly, J.M.; Bradbury, A. M., Martin, D.R., Byrne, M.E. “Emerging Therapies for Neuropathic Lysosomal Storage Disorders”, Progress in Neurobiology, 152, 166-180 (2017). PMCID: 27725193
Kelly, J.M.; Pearce, E. E.; Martin, D.R.; Byrne, M.E. “Lyoprotectants Modify and Stabilize Self-Assembly of Polymersomes”, Polymer, 87, 316-322 (2016).
Larsen, J. M.; Martin, D. R.; Byrne, M. E. “Recent Advances in Delivery through the Blood-Brain Barrier”, Current Topics in Medicinal Chemistry, 14, 1148–1160 (2014).
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